Corticospinal Neurons in Macaque Ventral Premotor Cortex with Mirror Properties: A Potential Mechanism for Action Suppression?
نویسندگان
چکیده
The discovery of "mirror neurons" in area F5 of the ventral premotor cortex has prompted many theories as to their possible function. However, the identity of mirror neurons remains unknown. Here, we investigated whether identified pyramidal tract neurons (PTNs) in area F5 of two adult macaques exhibited "mirror-like" activity. About half of the 64 PTNs tested showed significant modulation of their activity while monkeys observed precision grip of an object carried out by an experimenter, with somewhat fewer showing modulation during precision grip without an object or grasping concealed from the monkey. Therefore, mirror-like activity can be transmitted directly to the spinal cord via PTNs. A novel finding is that many PTNs (17/64) showed complete suppression of discharge during action observation, while firing actively when the monkey grasped food rewards. We speculate that this suppression of PTN discharge might be involved in the inhibition of self-movement during action observation.
منابع مشابه
Corticospinal mirror neurons
Here, we report the properties of neurons with mirror-like characteristics that were identified as pyramidal tract neurons (PTNs) and recorded in the ventral premotor cortex (area F5) and primary motor cortex (M1) of three macaque monkeys. We analysed the neurons' discharge while the monkeys performed active grasp of either food or an object, and also while they observed an experimenter carryin...
متن کاملMaking Mirrors: Premotor Cortex Stimulation Enhances Mirror and Counter-mirror Motor Facilitation
Mirror neurons fire during both the performance of an action and the observation of the same action being performed by another. These neurons have been recorded in ventral premotor and inferior parietal cortex in the macaque, but human brain imaging studies suggest that areas responding to the observation and performance of actions are more widespread. We used paired-pulse TMS to test whether d...
متن کاملMirror Neurons and Their Reflections
Human mirror neuron system is believed to provide the basic mechanism for social cognition. Mirror neurons were first discovered in 1990s in the premotor area (F5) of macaque monkeys. Besides the premotor area, mirror neuron systems, having different functions depending on their locations, are found in various cortical areas. In addition, the importance of cingulate cortex in mother-infant rela...
متن کاملMirror neurons
The term mirror neurons originally referred to neurons in the ventral premotor cortex of macaque monkeys (area F5, Figure 1a) that have the particularity of responding both when the monkey performs a particular action (e.g., grasping a peanut) and when the monkey perceives another individual performing a similar action. More recently the term mirror has been extended to areas of the human brain...
متن کاملThe body and objects represented in the ventral stream of the parieto-premotor network
The network between the parietal cortex and premotor cortex has a pivotal role in sensory-motor control. Grasping-related neurons in the anterior intraparietal area (AIP) and the ventral premotor cortex (F5) showed complementary properties each other. The object information for grasping is sent from the parietal cortex to the premotor cortex for sensory-motor transformation, and the backward si...
متن کامل